Beilstein J. Nanotechnol.2022,13, 245–254, doi:10.3762/bjnano.13.19
produce ampicillintrihydrate-loaded poly(lactic acid) (PLA) and PLA/poly(lactic-co-glycolic acid) (PLA/PLGA) polymeric nanofibers via electrospinning using 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as the solvent for local application in tissue engineering. The effects of ampicillintrihydrate
encapsulation efficiency (approx. 90%) and mechanical properties. The increase in the amount of ampicillintrihydrate caused an increase in the diameter and burst effect of the nanofibers. The drug release ended on the 7th and 3rd day with nanofibers containing 4% and 12% of drug, respectively. The prolonged
produced with enhanced encapsulation efficiency and mechanical properties, resulting in controlled and tailored release of ampicillintrihydrate for at least ten days. In conclusion, it was demonstrated that the addition of PLGA in different ratios and the amount of drug can be manipulated to obtain the
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Figure 1:
SEM images of nanofibers produced by changing the ampicillin trihydrate concentration (F1: 4%, F2: ...